Kentucky opened a 13-3 lead in less than six minutes, then scored the final 11 points of the half for a 39-13 lead at the break.
The Kentucky Wildcats begin their quest for a ninth national title in program history on Thursday with an opening round game against Abliene Christian.
Washington, UK's leading scorer and rebounder, missed the game with a foot injury and watched from the bench with his left foot in a cast.More news: Brie Larson Unicorn Store Trailer Reunites Her With Samuel L Jackson — Netflix
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Calipari said on Twitter that the sprain was confirmed after Washington was seen by a specialist.
Kentucky's Reid Travis, a graduate transfer from Stanford in his first NCAA Tournament game, racked up 18 points on 8-for-10 shooting, and freshman Tyler Herro added 14 points. His status for a potential game on Saturday is unclear, though Washington is now in a hard cast for "precautionary reasons".
The first NCAA Tournament appearance for Abilene Christian (27-7) didn't go well. He also pulled off six rebounds to help United Kingdom dominate the boards.
John Calipari attempted to quell the concerns of nervous Kentucky fans on the eve of the NCAA tournament. There was no further information on Washington's availability should Kentucky advance. The only exception was 2013, when the Wildcats failed to make the field and settled for the NIT.