The 21-year-old Osaka, trying to defend a title for the first time in her career, was routed 6-3, 6-1 by Switzerland's Belinda Bencic. Her triumph in this elite WTA premier mandatory tournament launched a stellar rise in 2018 that included a first Grand Slam title at the US Open.
Naomi Osaka followed Simona Halep through the exit door at the BNP Paribas Open on Tuesday as the top two players in the world were sent packing in the fourth round at Indian Wells. But she never found her feet against Bencic, whose crisp groundstrokes and precise service game propelled her to victory in 66 minutes.
"Honestly, she was just playing so well, and she's such an incredible player".
The world No. 23 player will next battle against fifth seed player Karolina Pliskova for her place in the semi-finals. She won everything in the past couple of months.
"I thought I was in good form".
"I think it's always a bit tricky whenever you change someone in the team, but I feel like for a first tournament we did really well", she said of her partnership with Jenkins, a former USA collegiate star who served as a hitting partner to Venus Williams from 2015 until the end of last season. "I'm very confident with my game right now".More news: Aussie dollar falls as U.S., China delay trade meeting; sterling falls
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"I didn't lose in the first round". But it just happens, one of those days.
The women's field lost its top two seeds as Romania's Halep, the 2015 Indian Wells victor, fell to Czech teenager Marketa Vondrousova 6-2, 3-6, 6-2. "The defense got me today", he said.
Naomi Osaka won her first career title at Indian Wells a year ago, propelling her to a career-best year in which she defeated Serena Williams for the U.S. Open title.
In-form Swiss Bencic blitzed the top seed, who surprisingly relinquished her crown following 28 unforced errors and just 10 winners.
Williams converted seven of nine break points and hit 20 winners as she earned a meeting with Mona Barthel, who stunned 15th seed Julia Goerges 7-5 1-6 6-4.
The 19-year-old, ranked 61st in the world, beat the Romanian 6-2 3-6 6-2.
Next up for Vondrousova - who ensured two teenagers reached the Indian Wells quarters for the first time since 2009 following Bianca Andreescu's upset of Wang Qiang, which set up a match against Garbine Muguruza - is Elina Svitolina.