"To be honest, I don't enjoy losing", Djokovic said after falling 6-4, 6-4 to 39th-ranked German Philipp Kohlschreiber in the third round.
Spain's Muguruza, a two-time Grand Slam champion now ranked 20th in the world, out-lasted seventh-ranked Kiki Bertens 5-7, 6-1, 6-4 while Williams, a seven-time Grand Slam victor, beat Germany's Mona Barthel 6-4, 6-4. In Kitzbuhel, he has a 18-9 match record (.667) - and on his most recent tournament appearance in 2018, he played a match on his wedding day. Her triumph in Australia made her No. 1 for the first time, but her time at the top has been rocky.
"[It's] not easy mentally to refresh your mindset and concentration and get the right intensity on the court so quickly after disappointing loss in singles".
"I was running too much and too defensive", the Romanian said to media. Tactic-wise, I played a clever match, I was aggressive with the forehand.
"I lose to Kholi and get absolutely shredded "same old Kyrgios", how about the guy is just good?"
Next up for Kohlschreiber is Gael Monfils, who owns a 13-2 record against the German. I congratulate him for playing tactically really well and getting me out of my comfort zone.More news: Solar storm WARNING: Apocalyptic storm that hit Earth could again
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"They are all special, but the first [title] in Munich in 2004 stands out, playing in front of the home crowd and in front of family and friends, was especially something special of course", he said.
The display of emotion didn't change anything as Kohlschreiber opened the second set with a service break and broke Djokovic again in the seventh game to give himself a chance to serve for the match.
The bottom half of the men's draw still includes No. 2 seed Rafael Nadal and fourth-seeded Roger Federer, both of whom breezed to victory.
The match with Federer will be another stern test for Wawrinka, a three-time Grand Slam champion who is climbing back up the rankings as he continues his return from double knee surgery. "Maybe I can turn around my career here".
Also, Czech teen Marketa Vondrousova shocked world No. 2 Simona Halep 6-2, 3-6, 6-2 the same day, notching her first victory over a top-five player to reach the WTA quarter-finals at Indian Wells.
World number two Nadal stayed on track to improve that number as he swept past Argentine Diego Schwartzman 6-3, 6-1 to reach the last 16. China's Wang Qiang failed to make it into the quarterfinals at the hands of Canada's Bianaca Andreescu 7-5, 6-2.