This makes it the fifth highest global opening weekend of all time and the second highest superhero opening weekend of all time - with Avengers: Infinity War taking the top spot at an opening of $640m.
The star paid a visit to an AMC cinema in Clifton, NJ, to mark the film's opening weekend.
It's the sixth largest worldwide debut ever.
Larson greeted excited fans before the screening.
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Captain Marvel's $455 million global opening weekend is the biggest global opening ever for a female-led movie.
Female power has reared up at the box office - in a big way. In fact, "Captain Marvel" just further proves that Feige and Co. have built a bulletproof empire.
In "Captain Marvel's" case, timing isn't everything, but it certainly does help.
Featuring select sequences specially formatted exclusively for IMAX® theatres and released on 1,377 IMAX screens worldwide, the film also claimed the Best IMAX March Opening Globally and delivered the Second Best IMAX Marvel Opening Globally behind last year's Avengers: Infinity War. In its second weekend, Tyler Perry's "A Madea Family Funeral" dropped 55 percent with $12 million.
Academy Award best-picture victor "Green Book" continued to see one of the largest Oscar bumps in years.