First baby born to mom using uterus from a deceased donor


The details of the first baby born following a uterus transplantation from a deceased donor were reported in a case study from Brazil, published in The Lancet. The organ was transplanted into a 32-year-old woman who had a disorder that left her without a uterus.

The uterus came from a 45-year-old woman who died from a brain hemorrhage.

The baby was delivered via Caesarean section at 35 weeks and three days, and weighed 2 550g according to the case study reported in The Lancet.

Nearly exactly a year after the baby's historic birth, Ejzenberg says she is developing normally and her mother feels "fulfilled".

Dr Dani Ejzenberg, from the Faculty of Medicine at Sao Paulo University, who led the team, said: "The use of deceased donors could greatly broaden access to this treatment, and our results provide proof-of-concept for a new option for women with uterine infertility". In one case in 2011, doctors in Turkey attempted to use a dead donor's womb to carry through a pregnancy, but the expectant mother miscarried two years later, even though the graft appeared healthy.

Brazilian doctors are now planning more transplants following the procedure.

These include the need to use several immune-suppressing drugs throughout the 9 months of pregnancy, which may have side effects on both the mom and the baby; having to deliver the baby and then remove the uterus in a cesarean hysterectomy procedure; a high rate of organ rejection; and a lengthy surgery that requires a multi-disciplinary approach among doctors. Until now, the only successful uterus transplants have involved living donors who are typically family members of the recipients.

Pregnancy was confirmed 10 days after implantation.

Research has since continued, with informed volunteers still opting to go through the discomfort and potential trauma in the hopes of giving birth.

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The study is also the first uterine transplantation in Latin America. The donated uterus was then removed from the patient after the birth.

Women who would be candidates for a uterus transplant would have absolute uterine infertility, meaning they don't have a uterus or that it is too damaged to support a pregnancy.

He said any doubts he had about the potential importance of uterus transplants were erased after meeting the mother of the first baby born after a live donor uterus transplant.

Unlike most transplantation surgeries "this is not a matter of life and death but more to satisfy a woman's desire to carry a child", Professor Salamonsen said. It is not clear yet, for instance, whether transplants from live or deceased donors will end up being more successful in the long run, she says.

Doctors perform the womb transplant procedure at the hospital in Sao Paulo, Brazil Dec. 15, 2017 in this picture handout obtained today.

The woman's eggs were fertilised before the operation and were implanted only seven months after the transplant.

Some who were born without a uterus, other had unexplained malformations, of sustained damaged during childbirth or infection.

Richard Kennedy, president of the International Federation of Fertility Societies (IFFS), said: "The IFFS welcomes this announcement which is an anticipated evolution from live donors with clear advantages and the prospect of increasing supply for women with hitherto untreatable infertility". It is estimated that one woman out of 500 would be the victim of an abnormality of the uterus into the world.