The injury setback will be frustrating for Martial, who had fought his way back into the national squad after scoring six goals in five league appearances for United.
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'He is still a young player, but one who, I hope, is seeing the importance he has taken in Manchester in recent weeks'.
Deschamps has been happy with Lacazette's return to form though initially favoured Martial - though the Manchester United star was not passed fit by France's doctors upon reporting to Clairefontaine.
City left-back Mendy will miss both fixtures after a scan in the French capital showed an issue with his knee.
The former Monaco forward continued his fine run in front of goal by netting a second-half penalty but Mendy had the last laugh as his City side ran out 3-1 winners at the Etihad.
A draw with the Netherlands can guarantee the world champions a top spot in the group and a chance of contending for the Nations League title next June.