The fire was burning toward Hidden Hills and because of the threat mandatory evacuations were issued north of the Ventura (101) Freeway from Valley Circle Boulevard to Lindero Canyon Road.
Around 10,000 acres of land was torched in the blaze by Thursday night, fire officials said.
The Los Angeles Fire Department reported at 7:53 a.m. Friday that a brush fire has also broken out in Griffith Park, near the zoo.
The Ventura County fire department said Friday that 75,000 homes were ordered evacuated in the two adjoining counties west of Los Angeles.
Friday morning, fire officials reported that the fire had jumped Highway 101 near the city of Calabasas.
And a blaze in Northern California sent terrified residents running for their lives as it closed in and destroyed parts of the town of Paradise, near Chico.
"There was really no firefight involved", said Capt. Scott McLean of the California Department of Forestry and Fire Protection, explaining that crews gave up on attacking the flames and instead helped people evacuate.
Borchard Community Center, Rancho Santa Susana Recreation Center, Camarillo Community Center, Thousand Oaks Teen Center, and Goebel Adult Community Center are open in Ventura County. "I pray everyone is safe", she wrote.More news: Samsung reveals foldable phone, Latest World News
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More than 400 firefighters from Ventura County, Los Angeles County, the City of Los Angeles and Cal Fire were battling the brush fire.
About two-thirds of the city of Malibu was ordered evacuated early Friday as a ferocious Southern California's wildfire roared toward the beachside community that is home for many Hollywood celebrities.
The Los Angeles and Ventura county fire departments say multiple buildings have been destroyed or damaged, but exact numbers were not available early Friday.
Residents took to social media to share their views of the flames almost consuming the hillside in Newbury Park, which borders Thousands Oaks to the west.
While no homes or businesses have been lost because of the fast-moving fire, a number of RVs and outbuildings have been burned and a firefighter suffered a minor injury, authorities said.
The flames are now threatening coastal areas further south, fire officials said.
The Santa Anas are strong, dry winds that high-pressure systems push from east to west, from the mountains and desert areas down into the Los Angeles area.
Fire crews Thursday morning were dealing with 40 miles per hour wind gusts.