Former world record holder Wilson Kipsang of Kenya was considered Kipchoge's biggest challenger and opted to stick with his own pace crew to run 61:30 through the half.
Kipchoge, 33, and a team of three pacers took off and passed through the first 5K in 14:24 and then 10K in 29:21. "But I didn't know I'd run 2:01".
Breaking down Kipchoge's time, however, is where the manner of his achievement really comes into focus.
Kenya's Olympic champion Eliud Kipchoge pulverised the marathon world record with a blistering run on Sunday, to shave off a staggering 78 seconds off the previous best and land the one major running crown that had eluded him.
Kipchoge said a record time was in his sights before the race, and after the opening few kilometres, it became clear his pacemakers would be pushed to the limit.
The time makes Cherono the fourth-best women's marathoner in history behind only Paula Radcliffe (2:15:25), Mary Keitany (2:17:01), and Tirunesh Dibaba (2:17:56).
Kipchoge kept up the pace to sprint through the Brandenburg Gate and complete a world record race that cements his reputation as one of the greatest runners of all time.More news: Tottenham 1-2 Liverpool
More news: Trump Accuses Democrats of Altering Statistics on Hurricane Deaths in Puerto Rico
More news: Documents show $10M moved from FEMA to ICE
The leading duo went through 25km in 1:12:24, and as Kipsang continued to fade in the second group, Kipchoge left Boit, who dropped out of the race.
Once he was alone on Sunday, Kipchoge ended up speeding up. By 40 kilometres, reached in 1:55:32, a world record was a certainty.
He accelerated over the final two kilometres and with his eyes on the finishing line shone the crowd with his infectious smile, striding to cut the tape in a new record time, by a whooping one minute and 18 seconds. He broke the record by a minute and seventeen seconds.
In the Kenyan city of Eldoret, celebrations were well underway as Kipchoge rounded off this most remarkable run.
Kenya's Gladys Cherono (right) and second placed Ethiopia's Ruti Aga celebrate after the women's category of the Berlin Marathon on September 16, 2018 in Berlin.
"I've run 2:00. I have run 2:01".
"It was hard. I ran my own race, I trusted my trainers, my programme and my coach".