Canelo and Alvarez square off at 8 p.m. ET.
Whilst the selection of judges remained a hot topic during the negotiations for the rematch, both fighters have promised the scorecards won't be needed this time around, with both looking to cement their status as the world's best with a fearsome knockout.
The Golovkin camp has been relentless in chastising Alvarez for the failed test and postponement of the rematch.
The rematch initially scheduled for May 5 earlier this year. It sparked a debate that left Golovkin openly questioning an excuse about contaminated meat in Mexico and whether Alvarez was clean for their first fight.
With one less world title on the line, talks between Golovkin's promoter, Tom Loeffler, and Canelo's handler, Oscar De La Hoya, became increasingly ill-tempered in the months that followed - and the fighters followed suit. "Like a real war".
Alvarez, an excellent counter puncher and boxer, also has the advantage of having gone 12 rounds with Triple G and understanding how to avoid getting hit with his biggest punches. But it was a tough, competitive matchup that delivered in other ways even without a victor at the end.
"I'm bothered by all the stupid things they've been saying and I've been using it as motivation in my training for this fight".More news: Tory Brexit rebels in retreat? Plot to topple Theresa May denied
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"I won the weigh-in, and tomorrow I'll win the fight", he said.
Canelo: I got excited from seeing all the fans it motivated me to do that right now.
"I think this fight could be it". Both men had to restrained during a heated altercation.
"Those are the kicks and screams of someone who is drowning", Alvarez said of Golovkin's doping claims.
Saturday's second meeting is expected to exceed that number thanks to a wild 12 months which included Alvarez (49-1-2, 34 KOs) failing a pair of drug tests which forced the original May 5 date to be postponed.
Abel Sanchez, who has trained Golovkin at his gym in the San Bernardino Mountains outside Los Angeles since 2011, agrees.
Alvarez said he got carried away by the atmosphere at the weigh-in. "In order to win a fight you have to want to win a fight".
Members of both entourages quickly got between the two fighters to head off a physical confrontation after Alvarez appeared to rush towards Golovkin, who didn't flinch.