Liverpool spent almost £180 million on four players during the summer transfer window, whilst Tottenham failed to sign a single player, and many are tipping Klopp's men to push Manchester City all the way for the Premier League title this term.
"It's our fifth season at Tottenham and if someone knows him really well I think we do".
"The Champions League - if I was Liverpool, I would kick it into touch", Neville said.
The 22-year-old midfielder could also be ruled out of next Tuesday evening's (Wednesday morning AEST) UEFA Champions League opener away to Inter Milan.
Pochettino described the 2-1 defeat at Watford as a "massive wake-up call" and said his side would have to be at their very best to have a chance of emulating last year's result against Juergen Klopp's Reds.
And there's no reason why the Reds can't go one better and win the competition for a sixth time.
Neville, who won just ten of his 28 games at Valencia in 2015/16 before being sacked, pointed to Liverpool's front three as lacking cover and said that they should forget the Champions League altogether during an interview with The Times.More news: Robert Scott, economist, says fears over Donald Trump tariffs overblown
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Discussing the worldwide break, Klopp said: "It's a big challenge but it's the same for all of us".
"Gary should come over and tell me exactly how that would work".
However, Alderweireld remained at the club over the summer, despite reported interest from Manchester United, Bayern Munich and Paris St Germain, and he has reintegrated into Pochettino's squad, starting the last three games.
I think it'll be tough but if they were to go of the Champions League and they had free weeks after Christmas, Saturday-to-Saturday they could be a real threat this season to City.
"If you want to win Premier League titles then you have to win these games, so Liverpool will be judged on this too". We don't play Champions League or what?
And another goal fest looks likely: There have been 149 goals scored in Premier League meetings between Tottenham and Liverpool - Arsenal vs Everton is the only fixture to have seen more in the competition (151).