Florence was expected to come ashore as a Category 4 hurricane around 8 a.m. Friday with 140 miles per hour winds.
Hurricane Florence seen from the International Space Station.
The storm's 175-mile (282 km) wide "cone of probability" suggests the storm will likely hit North Carolina's coast near Cape Fear, but storms fall outside the cone one-third of the time, according to The Weather Channel.
While Hurricane Florence has sparked state of emergency and mass evacuation, a very unfortunate weather graphic has managed to put a smile on those preparing for the storm.
The footage was captured by one of the National Oceanic and Atmospheric Administration (NOAA)'s Hurricane Hunters, planes given whimsical nicknames that chase down storms - "Kermit" and "Miss Piggy". "We just need to figure out how to make it through".
In Charleston, South Carolina, some residents were making preparations to leave Tuesday while others planned to ride out the storm.More news: US President's ex-aide jailed in Russian Federation probe
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The lingering storm could bring days of heavy rains, which could spark intense floods from SC to Virginia.
"If Florence comes ashore during high tide, it could be similar to [Hurricane] Sandy and push more water inland", he said. "With more than 300 miles of coastline in the path of the storm, it's important for [companies] like U-Haul to do what they can".
Hurricane warnings have been issued by the U.S. National Hurricane Center for portions of SC and North Carolina due to Hurricane Florence, according to the agency's 5 p.m. update on September 11, 2018.
Michelle Stober loaded up valuables at her home on Wrightsville Beach to drive back to her primary residence in Cary, North Carolina. Isolated tornadoes are also on the high end since we will be on the worst side of the storm. The forecast is for landfall to occur overnight Thursday into Friday morning.
Forecast models have said that several feet of heavy rain could cause flooding well inland from the coast.
While many coastal residents heeded mandatory evacuation orders, others boarded up homes and businesses and chose to fearless the storm, which is forecast to trigger severe flash flooding as it dumps as many as three feet (almost a meter) of rain in some areas. Tropical Storm Isaac was expected to pass south of Puerto Rico, Haiti, the Dominican Republic and Cuba, while Hurricane Helene was moving northward away from land.