Saul's lively performance had the Spanish media asking why he did not play a single minute at the World Cup despite being part of the squad, while forward Rodrigo, scorer of the winning goal, also gave the team a more direct feel.
For now, Kane is just happy to be back with players he shared such a special time with in Russian Federation over the summer.
The game was stopped for over five minutes while Shaw received treatment following a clash with Dani Carvajal. He allowed the players the morning off and liberated them from having to wake up at any particular time for breakfast.
England's defeat was their first in 25 competitive fixtures at Wembley.
The three points see Spain go top of UEFA Nations League Group 4, with the third team in the group, Croatia, yet to play their opener.
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Before the game, England coach Gareth Southgate had warned that his team still had much to prove on the global stage, claiming that the country's winning record against world football's elite has been "non-existent" since the World Cup success in 1966.
The turnaround was complete for Spain on 31 minutes as Rodrigo turned home Thiago Alacantara's in-swinging free-kick at the near post.
However, Luis Enrique's Spain side impressed throughout and drew level just two minutes later, with the superb Saul Niguez scoring courtesy of a crisp finish from inside the box.
Luis Enrique has revealed that David De Gea believed he was fouled for Danny Welbeck's disallowed goal in Spain's victory over England on Saturday evening.
Luke Shaw has had rotten luck with injuries.
"Thank you for all the love and support I am doing fine and am in the best hands", the Manchester United left-back tweeted.
"That balance with the left footer for us, with him and Danny (Rose), was an advantage in several situations". De Gea was subject to vociferous attacks by sections of the public and the media for his performances with Spain in Russian Federation at the World Cup 2018.