Update: City have since released an official statement confirming the news that De Bruyne has suffered a lateral collateral lesion in his right knee and will be out for around three months.
City led 2-0 and seemed on course to wrap up their title win before a second-half comeback postponed their celebrations for a week.
The 27-year-old sustained the setback during a training session on Wednesday and, following a visit to specialist Dr Ramon Cugat in Barcelona on Thursday, City have confirmed his diagnosis.
"This can happen because you build an unbelievable stadium for Tottenham Hotspur - sometimes there are delays, this kind of thing happens. We don't look at the other teams, we really only try to make the best of our situation, and that will hopefully work".
"It will be a big miss like last season with Benjamin Mendy".
"We'll never know, but my opinion is that we demanded a lot of the players".More news: 'No chance' Willian would have stayed at Chelsea under Conte
More news: Gunmen attack intelligence service centre in Afghan capital Kabul
More news: Manchester City’s Kevin De Bruyne suffers knee injury in training
One idea would be to reverse the game and stage it at the Etihad, but this would leave City facing the prospect of finishing the season with four away games out of the last five. When you are fresh here, fresh on your legs, it doesn't happen.
ESPN FC's Shaka Hislop assesses how Man City will fare in Kevin De Bruyne's absence following his recent knee injury.
"My advice to him now is to rest, take the holidays he didn't get in these two or three weeks, do it now".
The midfielder won the 2010 World Cup, as well as the 2008 and 2012 European Championships, before announcing his global retirement earlier this week.
His statistics are quite frankly ridiculous as the Spaniard has scored 47 goals and provided 93 assists during the past eight Premier League seasons and his Fantasy Football statistics bare comparison with any of his contemporaries.