The diagnosis ends his rookie season nearly immediately after it had begun.
Back from a torn ACL last summer, Patriots defensive end Derek Rivers couldn't have asked much more from his first game rep than a shot to clobber Washington running back Rob Kelley for a 1-yard stop as he did Thursday.
Guice was injured in Washington's preseason opener at New England on Thursday night and could be seen on the sideline with ice on his knee.
A second-round draft choice out of LSU, Guice had 19 yards on six carries before leaving the game. For fantasy players who already drafted Guice, it might feel like your season is already over.
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Perine had been mentioned as a possible cut earlier this summer, and while that's unlikely to happen now, it should give us an idea as to what the coaching staff thinks of him.
Rookie Derrius Guice's much-anticipated debut season in the National Football League is already over before it began. But can he run with the power and explosiveness that Guice was expected to bring?
Schefter also mentioned Gronkowski's restructure from last season.
We know Chris Thompson figures to be a big part of the backfield workforce, but he's also coming off a season-ending injury previous year with a fractured right fibula Other candidates include Byron Marshall or Kapri Bibbs, who have some big-play ability.
Beyond Kelley, Thompson and Perine, the Redskins have Kapri Bibbs, Byron Marshall and undrafted Martez Carter as running backs in camp.