Toronto Police said they had responded to a call at around 10:00 pm (0200 GMT Monday) in the city's Greektown district, at the intersection of the Danforth and Logan avenues areas.
"At this time, there is no national-security nexus to the investigation", said a spokesperson for the ministry of public safety. Police previously identified the other person killed in the shooting as 18-year-old Reese Fallon. The 13 injured include six women and girls, as well as seven men.
Toronto police say they have no information that he has traveled overseas recently.
Friends described Hussain as quiet and polite.
"I'm devastated that something like this could possibly happen in this neighbourhood, that it could happen in the city all together", Giaouridis said.
"This is my community, and I just wanted to be around people", said Angel Riccio.
Hussain lived with his parents in an apartment and a police search of the premises turned up a firearm. Hussain died from a gunshot wound, but it's unclear if a police officer shot him or he shot himself.More news: Amazon earnings: What to expect
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Police identified the gunman as Faisal Hussain of Toronto.
Toronto has been rattled by a string of violent incidents this year.
In April, a driver deliberately ploughed his white Ryder rental van into a lunch-hour crowd, killing 10 people and injuring 15 along a roughly mile-long (1.6-km) stretch of sidewalk thronged with pedestrians. The following month, more than a dozen people were injured after a homemade bomb ripped through an Indian restaurant in May in nearby Mississauga.
Doug Ford hugs a man at the start of the march. The name of the young girl, who was from the Greater Toronto area, has not been released per the wishes of her family.
The older brother of the suspected Danforth shooter was facing drug charges in Saskatoon around the same time the gun used in the deadly shooting was stolen in the city. The city has seen 23 gun homicides so far this year, compared to 16 fatal shootings in the first half of 2017.
Kaitlyn Riordan, artistic director of "Shakespeare in the Ruff", said her initial reaction was "to be very afraid", and to stay indoors.
Council members discussed gun violence, its causes, its effects and potential solutions during a meeting that began Tuesday morning and lasted into the evening.
But his family said in the statement that they'd sought treatment.
"Why does anyone in this city need to have a gun at all?" he asked in an address to city councillors early on Monday. But, as the Sun has reported, Hussain was visited by law enforcement over concerns of visiting pro-ISIL websites, as well as dealt with under the Mental Health Act by Toronto Police on several occasions for concerns of behaviour and violence.