The state Department of Health and Human Services announced the death on Friday as a warning to others to protect from mosquito-borne illnesses.
The state has confirmed it's first death this year from the West Nile Virus, and it happened in Eastern Carolina.
DHHS is not releasing more specifics on the case to protect patient confidentiality.
Symptoms of a West Nile virus infection include headaches, fevers and nausea.
"These infections are rare, but this is a tragic reminder that they can be fatal", State Public Health Veterinarian Carl Williams said in a news release.
Bosch says wear long sleeves if you can when outdoors, use mosquito repellent and avoid being outdoors at dawn and dusk, when mosquitoes are most active.
According to the District, the confirmation of infected mosquitoes comes less than one week after the District confirmed chickens tested positive for antibodies against West Nile virus near Knightsen.More news: Zuckerberg attempts to clarify Holocaust denial comments
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According to the Centers for Disease Control and Prevention, most people who become infected with West Nile virus experience no symptoms or a mild, flu-like illness.
Mosquitoes in North Carolina are also known to carry other illnesses that can infect both humans and animals.
People bitten by mosquitoes may be infected by the virus.
Install or fix screens on windows and doors to keep mosquitoes outside, and if possible, use air conditioning.
To reduce the opportunity for mosquitoes to breed, the department suggests ensuring draining pipes are properly sloped and to eliminate sources of standing water around your home, including birdbaths, pet dishes and garbage cans.
No people or birds have tested positive for West Nile virus in San Diego County this year.
Officials are advising the public to remove standing water as well.