The plane, which had been expected at the Aviodrome, 'crashed in South Africa during take-off on a test flight, ' it said.
"There is smoke all over and paramedics are on the scene".
Eyewitnesses described seeing the plane attempt to veer toward Wonderboom airport, then hearing an explosion.
Images from the site showed the plane broken into several pieces.
At least 18 other people have also been injured from the crash on Tuesday afternoon, according to ER24.
He said: "Initial reports show that approximately 20 people had sustained injuries ranging from minor to critical".
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Shortly afterwards the plane crashed into the factory.
Paramedic Xander Loubser from BestCare Ambulance Service said: "There are critical patients".
It had been due to fly to Aviodrome via east Africa, through Egypt, Croatia, Austria to the Netherlands.
The plane was a Dutch cargo MAC Martin's Air Charter owned by Air France-KLM.
The large plane appeared to have crashed through a nearby building, the official said. It had just been refurbished for 350,000 euros ($410,000) at Wonderboom.
South African Civil Aviation Authority said it will issue a statement with further details on Wednesday.