His costar, Michael B. Jordan, who played the villain Erik Killmonger, won Best Villain.
The Netflix original drama took home three of the evening's 14 awards, including Best Show.
"I still can't believe how much they paid me", Latifah joked.
Love, Simon was a surprise hit in cinemas and was credited with being the first mainstream teenage film to feature a gay lead character and was lauded for helping young people come out. Its massive popularity overshadowed competing films like Wonder Woman and Avengers: Infinity War.
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"So, this is gonna live at your house", Boseman said, handing over the award to Shaw Jr.
Lady Gaga is five-foot two inches tall and still growing.
Meanwhile, Finn Wolfhard also won for Best On-Screen Team with his It co-stars.
Jurassic World and Avengers: Infinity War actor Chris Pratt was given the annual Generation Award, joining the ranks of previous winners Tom Cruise, Sandra Bullock and Will Smith.
During his acceptance speech for the coveted Generation Award, the "Guardians of the Galaxy" star told those in attendance - and those tuned in via the live broadcast - that "God is real".
The night included several performances, including by duo Halle Bailey, left, and Chloe Bailey of Chloe X Halle.
The Award goes to "an artist who has shown us a variety of impressive roles, a personal and professional flair and of course, an awesome level of talent" - which yeah, describes Pratt, a man we sometimes forget is super Christian, and maybe just is Andy Dwyer but buff now (???). "If you don't, you'll suffocate". It's easy and it's so good for your soul.