City have made a habit of breaking new statistical ground while turning the title race into a procession.
It was Sir Alex Ferguson's United who previously held the record, having finished 18 points ahead of second-placed Arsenal in the 1999-2000 season, and City needed Fergie time to finally find a breakthrough deep into stoppage time at St Mary's.
However, Gabriel Jesus' late victor at Southampton took City to 32 victories, which means that they now also have the overall record for an English top-flight season - previously held by Tottenham Hotspur, who recorded 31 wins in the old First Division in 1960-61.More news: Alberta tries ads to win hearts and minds of anti-pipeline groups
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Here, we have a look at some of their most astonishing numbers. Defeats to Liverpool and Manchester United and draws against Everton, Crystal Palace, Burnley and Huddersfield Town are the only blots on their record.
Premier League champions Manchester City end their campaign with a trip to Southampton. Their 16 away wins also represents a competition best.
The Blues broke a Premier League points record by reaching 97 with the win over Brighton in midweek and the record for goals scored in a season, as they took their total to 105. Guardiola's team have been focused on rewriting the record books since clinching the English title nearly a month ago and they added one last landmark achievement on the final day of the season.
In addition, their goal difference of plus 79 is the biggest in Premier League history.